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HIT212525564
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HIT212525564
  • HIT ID:HIT212525564
  • Cas No:30368-42-4
  • 常用名:Dalbergioidin
  • IUPAC:3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one
    IUPAC:3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one
  • InChI key:WNHXBLZBOWXNQO-UHFFFAOYSA-N
  • 分子式:C15H12O6
  • 分子量:288.255
  • 氢键供体数 (HBD):4
  • 氢键受体数 (HBA):6
  • LogP:2.424
  • SMILES:Oc1ccc(C2COc3cc(O)cc(O)c3C2=O)c(O)c1
    SMILES:Oc1ccc(C2COc3cc(O)cc(O)c3C2=O)c(O)c1
  • Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway.
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    TargetMolSC
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    ¥ 11,650.00
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    AnyMoleSC
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  • 供应商
    AnalyticonSC
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    4-5周
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    85%
    ¥ 3,289.00
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