Name: Angiotensin II human acetate
Rating: 5 (10 reviews)

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HIT ID:HIT212653294
Cas No:68521-88-0
常用名:Angiotensin II human acetate
别名:血管紧张素II, DRVYIHPF acetate, Angiotensin II acetate, Ang II acetate
别名:血管紧张素II, DRVYIHPF acetate, Angiotensin II acetate, Ang II acetate
IUPAC:(3S)-3-amino-3-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}butyl]carbamoyl}propanoic acid; acetic acid
IUPAC:(3S)-3-amino-3-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}butyl]carbamoyl}propanoic acid; acetic acid
InChI key:VBTZKFAHKJXHBA-PIONDTTLSA-N

分子式:C52H75N13O14
分子量:1106.249
氢键供体数 (HBD):14
氢键受体数 (HBA):17
LogP:-5.2192154
SMILES:CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
SMILES:CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O

Angiotensin II human acetate 是肾素-血管紧张素系统中的主要血管收缩肽，通过与AT1R和AT2R受体结合调节血压，刺激交感神经，促进醛固酮合成和肾脏功能，诱导血管平滑肌细胞增生和胶原合成，导致血管及心肌增厚和纤维化，同时促进细胞凋亡和内皮毛细血管形成。常用于诱导高血压和心脏肥大模型。

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