Name: Navoximod
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212661402
Cas No:1402837-78-8
常用名:Navoximod
别名:NLG-919, GDC-0919
IUPAC:(1R,4r)-4-[(1R)-2-[(5S)-6-fluoro-5H-imidazo[4,3-a]isoindol-5-yl]-1-hydroxyethyl]cyclohexan-1-ol
IUPAC:(1R,4r)-4-[(1R)-2-[(5S)-6-fluoro-5H-imidazo[4,3-a]isoindol-5-yl]-1-hydroxyethyl]cyclohexan-1-ol
InChI key:YGACXVRLDHEXKY-WXRXAMBDSA-N

分子式:C18H21FN2O2
分子量:316.376
氢键供体数 (HBD):2
氢键受体数 (HBA):3
LogP:1.7565641
SMILES:O[C@H](C[C@H]1c2c(cccc2F)-c2cncn12)[C@H]1CC[C@H](O)CC1 |wU:16.18,wD:1.0,19.22,3.2,(-2.52,-5.66,;-1.2,-6.45,;.15,-5.71,;.18,-4.17,;1.44,-3.29,;.99,-1.82,;2.05,-.69,;3.55,-1.04,;3.99,-2.51,;2.94,-3.64,;3.39,-5.11,;-.55,-1.78,;-1.77,-.86,;-3.04,-1.74,;-2.59,-3.21,;-1.05,-3.24,;-1.23,-7.99,;.09,-8.79,;.06,-10.33,;-1.29,-11.07,;-1.32,-12.61,;-2.61,-10.28,;-2.58,-8.74,)|
SMILES:O[C@H](C[C@H]1c2c(cccc2F)-c2cncn12)[C@H]1CC[C@H](O)CC1 |wU:16.18,wD:1.0,19.22,3.2,(-2.52,-5.66,;-1.2,-6.45,;.15,-5.71,;.18,-4.17,;1.44,-3.29,;.99,-1.82,;2.05,-.69,;3.55,-1.04,;3.99,-2.51,;2.94,-3.64,;3.39,-5.11,;-.55,-1.78,;-1.77,-.86,;-3.04,-1.74,;-2.59,-3.21,;-1.05,-3.24,;-1.23,-7.99,;.09,-8.79,;.06,-10.33,;-1.29,-11.07,;-1.32,-12.61,;-2.61,-10.28,;-2.58,-8.74,)|

Navoximod (GDC-0919) 是 IDO(indoleamine-(2,3)-dioxygenase) 抑制剂，Ki=7 nM/，EC50=75 nM。

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