Name: Lyn peptide inhibitor acetate
Rating: 5 (10 reviews)

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HIT ID:HIT212661692
Cas No:2918771-52-3
常用名:Lyn peptide inhibitor acetate
别名:Lyn peptide inhibitor acetate(222018-18-0 free base)
别名:Lyn peptide inhibitor acetate(222018-18-0 free base)
IUPAC:(4S)-4-{[(1S)-1-{[(1S)-5-amino-1-{[(2S,3S)-1-[(2S)-2-{[(2S)-3-carbamoyl-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]carbamoyl}pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]carbamoyl}pentyl]carbamoyl}-3-carboxypropyl]carbamoyl}-4-[(2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-3-(4-hydroxyphenyl)-2-{2-[(2S)-3-(4-hydroxyphenyl)-2-octadecanamidopropanamido]acetamido}propanamido]pentanamido]-4-methylpentanamido]pentanamido]pentanamido]hexanamido]-3-(1H-indol-3-yl)propanamido]butanoic acid; acetic acid
IUPAC:(4S)-4-{[(1S)-1-{[(1S)-5-amino-1-{[(2S,3S)-1-[(2S)-2-{[(2S)-3-carbamoyl-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]carbamoyl}pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]carbamoyl}pentyl]carbamoyl}-3-carboxypropyl]carbamoyl}-4-[(2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-3-(4-hydroxyphenyl)-2-{2-[(2S)-3-(4-hydroxyphenyl)-2-octadecanamidopropanamido]acetamido}propanamido]pentanamido]-4-methylpentanamido]pentanamido]pentanamido]hexanamido]-3-(1H-indol-3-yl)propanamido]butanoic acid; acetic acid
InChI key:VLGOBVFKVGWHSY-FMHIDZNUSA-N

分子式:C117H188N30O26
分子量:2430.975
氢键供体数 (HBD):32
氢键受体数 (HBA):35
LogP:-5.7936687
SMILES:CC(O)=O.CCCCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(N)=O
SMILES:CC(O)=O.CCCCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(N)=O

Lyn peptide inhibitor acetate(222018-18-0 free base) 是一种有效的细胞渗透性 Lyn 偶联 IL-5 受体信号通路抑制剂，同时保持其他信号完整。它阻断 Lyn 活化并抑制 Lyn 酪氨酸激酶与 IL-3/GM-CSF/IL-5 受体的 βc 亚基的结合。它可用于哮喘、过敏和其他嗜酸性粒细胞疾病的研究。

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