Name: Tanshinone IIB
Rating: 5 (10 reviews)

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HIT ID:HIT212665945
Cas No:17397-93-2
常用名:Tanshinone IIB
别名:丹参酮ⅡB
IUPAC:(6S)-6-(hydroxymethyl)-1,6-dimethyl-6H,7H,8H,9H,10H,11H-phenanthro[1,2-b]furan-10,11-dione
IUPAC:(6S)-6-(hydroxymethyl)-1,6-dimethyl-6H,7H,8H,9H,10H,11H-phenanthro[1,2-b]furan-10,11-dione
InChI key:XDUXBBDRILEIEZ-LJQANCHMSA-N

分子式:C19H18O4
分子量:310.349
氢键供体数 (HBD):1
氢键受体数 (HBA):3
LogP:4.84
SMILES:Cc1coc-2c1C(=O)C(=O)c1c3CCC[C@](C)(CO)c3ccc-21
SMILES:Cc1coc-2c1C(=O)C(=O)c1c3CCC[C@](C)(CO)c3ccc-21

Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons; TSB is effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development.

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