Name: MGAT2-IN-1
Rating: 5 (10 reviews)

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HIT ID:HIT212666047
Cas No:1800025-30-2
常用名:MGAT2-IN-1
IUPAC:N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide
IUPAC:N-(4-chloro-2,6-difluorophenyl)-1-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]pyrimidin-2-yl}-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-5-sulfonamide
InChI key:VSZRYLHBOKTNBO-UHFFFAOYSA-N

分子式:C27H21ClF5N7O3S
分子量:654.01
氢键供体数 (HBD):1
氢键受体数 (HBA):7
LogP:4.3966904
SMILES:Cn1nc(cc1-c1cnc(nc1)N1CCc2cc(cc(N3CCCC3=O)c12)S(=O)(=O)Nc1c(F)cc(Cl)cc1F)C(F)(F)F
SMILES:Cn1nc(cc1-c1cnc(nc1)N1CCc2cc(cc(N3CCCC3=O)c12)S(=O)(=O)Nc1c(F)cc(Cl)cc1F)C(F)(F)F

MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).

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