Name: CBP/p300-IN-5
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212666396
Cas No:1889284-33-6
常用名:CBP/p300-IN-5
别名:P300/CBP-IN-5
IUPAC:2-[(3'R,4S)-3'-fluoro-5'-{1-[(methylcarbamoyl)methyl]-1H-pyrazol-4-yl}-2,5-dioxo-2',3'-dihydrospiro[imidazolidine-4,1'-inden]-1-yl]-N-[(4-fluorophenyl)methyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide
IUPAC:2-[(3'R,4S)-3'-fluoro-5'-{1-[(methylcarbamoyl)methyl]-1H-pyrazol-4-yl}-2,5-dioxo-2',3'-dihydrospiro[imidazolidine-4,1'-inden]-1-yl]-N-[(4-fluorophenyl)methyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide
InChI key:SWXCHCQCWFXILM-DAXQEMQKSA-N

分子式:C29H27F5N6O4
分子量:618.565
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:2.184828
SMILES:CNC(=O)Cn1cc(cn1)-c1ccc2c(c1)[C@H](F)C[C@]21NC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O
SMILES:CNC(=O)Cn1cc(cn1)-c1ccc2c(c1)[C@H](F)C[C@]21NC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O

P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).

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