Name: PF-06751979
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT212666475
Cas No:1818339-66-0
常用名:PF-06751979
IUPAC:N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4H,4aH,5H,6H,8H,8aH-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl}-5-(difluoromethoxy)pyridine-2-carboxamide
IUPAC:N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4H,4aH,5H,6H,8H,8aH-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl}-5-(difluoromethoxy)pyridine-2-carboxamide
InChI key:ZLZUHACSRMOLLV-RAALSFIWSA-N

分子式:C18H19F2N5O3S2
分子量:455.5
氢键供体数 (HBD):2
氢键受体数 (HBA):7
LogP:3.1651373
SMILES:[H][C@]12CSC(N)=N[C@]1(CO[C@@H](C)C2)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1 |c:5|
SMILES:[H][C@]12CSC(N)=N[C@]1(CO[C@@H](C)C2)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1 |c:5|

PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).

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