Name: PI3K-IN-6
Rating: 5 (10 reviews)

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HIT ID:HIT212666500
Cas No:1842380-77-1
常用名:PI3K-IN-6
IUPAC:8-chloro-2-[(1S)-1-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]ethyl]-6-fluoro-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-4-one
IUPAC:8-chloro-2-[(1S)-1-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]ethyl]-6-fluoro-3-(1H-pyrazol-3-yl)-3,4-dihydroquinazolin-4-one
InChI key:SAWISWWSHNTVLW-LURJTMIESA-N

分子式:C17H14Cl2FN9O
分子量:450.26
氢键供体数 (HBD):4
氢键受体数 (HBA):8
LogP:2.9069638
SMILES:C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1
SMILES:C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1

PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).

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