Name: A-887826
Rating: 5 (10 reviews)

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HIT ID:HIT212666881
Cas No:1266212-81-0
常用名:A-887826
IUPAC:5-(4-butoxy-3-chlorophenyl)-N-{[2-(morpholin-4-yl)pyridin-3-yl]methyl}pyridine-3-carboxamide
IUPAC:5-(4-butoxy-3-chlorophenyl)-N-{[2-(morpholin-4-yl)pyridin-3-yl]methyl}pyridine-3-carboxamide
InChI key:JPJGFWKHSMUKFO-UHFFFAOYSA-N

分子式:C26H29ClN4O3
分子量:480.99
氢键供体数 (HBD):1
氢键受体数 (HBA):6
LogP:4.238189
SMILES:CCCCOc1ccc(cc1Cl)-c1cncc(c1)C(=O)NCc1cccnc1N1CCOCC1
SMILES:CCCCOc1ccc(cc1Cl)-c1cncc(c1)C(=O)NCc1cccnc1N1CCOCC1

A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.

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