Name: A-9758
Rating: 5 (10 reviews)

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HIT ID:HIT212666882
Cas No:2055271-22-0
常用名:A-9758
IUPAC:1-(2,4-dichloro-3-{[1,4-dimethyl-6-(trifluoromethyl)-1H-indol-2-yl]methyl}benzoyl)piperidine-4-carboxylic acid
IUPAC:1-(2,4-dichloro-3-{[1,4-dimethyl-6-(trifluoromethyl)-1H-indol-2-yl]methyl}benzoyl)piperidine-4-carboxylic acid
InChI key:NVDKGFYFKVWJLJ-UHFFFAOYSA-N

分子式:C25H23Cl2F3N2O3
分子量:527.37
氢键供体数 (HBD):1
氢键受体数 (HBA):3
LogP:6.122034
SMILES:Cc1cc(cc2n(C)c(Cc3c(Cl)ccc(C(=O)N4CCC(CC4)C(O)=O)c3Cl)cc12)C(F)(F)F
SMILES:Cc1cc(cc2n(C)c(Cc3c(Cl)ccc(C(=O)N4CCC(CC4)C(O)=O)c3Cl)cc12)C(F)(F)F

A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis.

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