Name: CT-721
Rating: 5 (10 reviews)

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HIT ID:HIT212666934
Cas No:1388710-60-8
常用名:CT-721
IUPAC:(1S)-N-[3-(2-{6-chloroimidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methylphenyl]-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-indene-5-carboxamide
IUPAC:(1S)-N-[3-(2-{6-chloroimidazo[1,2-b]pyridazin-3-yl}ethynyl)-4-methylphenyl]-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-indene-5-carboxamide
InChI key:UKRXMBYVZRAMAF-MHZLTWQESA-N

分子式:C30H29ClN6O
分子量:525.05
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:5.4563117
SMILES:CN1CCN(CC1)[C@H]1CCc2cc(ccc12)C(=O)Nc1ccc(C)c(c1)C#Cc1cnc2ccc(Cl)nn12
SMILES:CN1CCN(CC1)[C@H]1CCc2cc(ccc12)C(=O)Nc1ccc(C)c(c1)C#Cc1cnc2ccc(Cl)nn12

CT-721 is a potent and time-dependent Bcr-Abl kinase inhibitor with an IC50 of 21.3 nM against wild-type Bcr-Abl kinase and has anti-chronic myeloid leukemia (CML) activity.

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