Name: DC4SMe
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212667024
Cas No:615538-47-1
常用名:DC4SMe
IUPAC:{[(1S)-1-(chloromethyl)-3-(5-{5-[3-(methyldisulfanyl)propanamido]-1H-indole-2-amido}-1H-indole-2-carbonyl)-1H,2H,3H-benzo[e]indol-5-yl]oxy}phosphonic acid
IUPAC:{[(1S)-1-(chloromethyl)-3-(5-{5-[3-(methyldisulfanyl)propanamido]-1H-indole-2-amido}-1H-indole-2-carbonyl)-1H,2H,3H-benzo[e]indol-5-yl]oxy}phosphonic acid
InChI key:GUHZUPDFYIAIMU-OAQYLSRUSA-N

分子式:C35H31ClN5O7PS2
分子量:764.2
氢键供体数 (HBD):6
氢键受体数 (HBA):6
LogP:4.9554687
SMILES:CSSCCC(=O)Nc1ccc2[nH]c(cc2c1)C(=O)Nc1ccc2[nH]c(cc2c1)C(=O)N1C[C@@H](CCl)c2c1cc(OP(O)(O)=O)c1ccccc21
SMILES:CSSCCC(=O)Nc1ccc2[nH]c(cc2c1)C(=O)Nc1ccc2[nH]c(cc2c1)C(=O)N1C[C@@H](CCl)c2c1cc(OP(O)(O)=O)c1ccccc21

The IC50s of DC4SMe on Ramos, Namalwa and HL60 / s cancer cells were 1.9 nM, 2.9 nM and 1.8 nM, respectively. DC4SMe can be used for targeted therapy of tumors. DC4SMe is a phosphate prodrug of the cytotoxic DNA alkylating agent DC4 and can be used in the synthesis of antibody-drug conjugates (ADC).

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~