Dot1L-IN-2 | CAS 1940206-71-2 | AnyMole

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HIT212667132

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HIT212667132

HIT ID:HIT212667132
Cas No:1940206-71-2
常用名:Dot1L-IN-2
IUPAC:N4-methyl-N2-{2-methyl-1-[2-({3-methyl-3H-imidazo[4,5-b]pyridin-6-yl}oxy)phenyl]-1H-indol-6-yl}pyrimidine-2,4-diamine
IUPAC:N4-methyl-N2-{2-methyl-1-[2-({3-methyl-3H-imidazo[4,5-b]pyridin-6-yl}oxy)phenyl]-1H-indol-6-yl}pyrimidine-2,4-diamine
InChI key:RQVLGMREYUFLPQ-UHFFFAOYSA-N

分子式:C27H24N8O
分子量:476.544
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:4.5756516
SMILES:CNc1ccnc(Nc2ccc3cc(C)n(-c4ccccc4Oc4cnc5n(C)cnc5c4)c3c2)n1
SMILES:CNc1ccnc(Nc2ccc3cc(C)n(-c4ccccc4Oc4cnc5n(C)cnc5c4)c3c2)n1

Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively.

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TargetMolSC
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6-8周
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-
¥ 11,700.00
1

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