Name: ACHN-975
Rating: 5 (10 reviews)

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HIT ID:HIT212667238
Cas No:1410809-36-7
常用名:ACHN-975
IUPAC:(2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide
IUPAC:(2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide
InChI key:GOCUUDXEOKIQRU-IXDOHACOSA-N

分子式:C20H23N3O4
分子量:369.421
氢键供体数 (HBD):5
氢键受体数 (HBA):5
LogP:-0.048642907
SMILES:CC(C)(N)[C@H](NC(=O)c1ccc(cc1)C#CC#C[C@@H]1C[C@H]1CO)C(=O)NO
SMILES:CC(C)(N)[C@H](NC(=O)c1ccc(cc1)C#CC#C[C@@H]1C[C@H]1CO)C(=O)NO

ACHN-975 is a highly potent and selective LpxC inhibitor, demonstrating subnanomolar inhibitory activity. It effectively targets a broad spectrum of gram-negative bacteria, with low minimum inhibitory concentration (MIC) values (≤1 μg/mL)[1].

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