Name: Boc-C1-PEG3-C4-OH
Rating: 5 (10 reviews)

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HIT ID:HIT212667488
Cas No:2376724-97-7
常用名:Boc-C1-PEG3-C4-OH
IUPAC:tert-butyl 2-(2-{2-[(6-hydroxyhexyl)oxy]ethoxy}ethoxy)acetate
IUPAC:tert-butyl 2-(2-{2-[(6-hydroxyhexyl)oxy]ethoxy}ethoxy)acetate
InChI key:RFJQECXXHSDFPN-UHFFFAOYSA-N

分子式:C16H32O6
分子量:320.426
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:1.4847932
SMILES:CC(C)(C)OC(=O)COCCOCCOCCCCCCO
SMILES:CC(C)(C)OC(=O)COCCOCCOCCCCCCO

Boc-C1-PEG3-C4-OH is an Alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs, which are characterized by their structure comprising two distinct ligands tethered by a linker. One ligand of PROTACs binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the targeted degradation of specific proteins[1].

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