Name: E3 ligase Ligand 10
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT212667661
Cas No:1073560-68-5
常用名:E3 ligase Ligand 10
IUPAC:(2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-3,3-diphenylpropanoic acid
IUPAC:(2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-3,3-diphenylpropanoic acid
InChI key:GZMLKDJDSMXRGP-HCVICXAGSA-N

分子式:C47H52N4O7
分子量:784.954
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:6.8446803
SMILES:C[C@H](N(C)C(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(O)=O
SMILES:C[C@H](N(C)C(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(O)=O

E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].

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