Name: Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH
Rating: 5 (10 reviews)

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HIT ID:HIT212667693
Cas No:2351103-63-2
常用名:Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH
常用名:Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH
别名:E3 ligase Ligand-Linker Conjugates 49, Cereblon Ligand-Linker Conjugates 14
别名:E3 ligase Ligand-Linker Conjugates 49, Cereblon Ligand-Linker Conjugates 14
IUPAC:1-[(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)carbamoyl]-2,8,11,17-tetraoxanonadecan-19-oic acid
IUPAC:1-[(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)carbamoyl]-2,8,11,17-tetraoxanonadecan-19-oic acid
InChI key:KDYIZKATTGMJTL-UHFFFAOYSA-N

分子式:C31H44N4O11
分子量:648.71
氢键供体数 (HBD):4
氢键受体数 (HBA):12
LogP:0.36706567
SMILES:OC(=O)COCCCCCOCCOCCCCCOCC(=O)NCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
SMILES:OC(=O)COCCCCCOCCOCCCCCOCC(=O)NCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest.

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