Name: Pomalidomide-PEG1-C2-N3
Rating: 5 (10 reviews)

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HIT ID:HIT212667694
Cas No:2271036-44-1
常用名:Pomalidomide-PEG1-C2-N3
别名:E3 ligase Ligand-Linker Conjugates 50, Cereblon Ligand-Linker Conjugates 13
别名:E3 ligase Ligand-Linker Conjugates 50, Cereblon Ligand-Linker Conjugates 13
IUPAC:4-{[2-(2-azidoethoxy)ethyl]amino}-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
IUPAC:4-{[2-(2-azidoethoxy)ethyl]amino}-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
InChI key:NJPMWHWTBBYBDY-UHFFFAOYSA-N

分子式:C17H18N6O5
分子量:386.368
氢键供体数 (HBD):2
氢键受体数 (HBA):8
LogP:1.639
SMILES:[N-]=[N+]=NCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
SMILES:[N-]=[N+]=NCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are commonly used in PROTAC technology. Utilizing Pomalidomide-PEG1-C2-N3, it is possible to design a selective CDK6 PROTAC degrader known as CP-10. CP-10 effectively induces the degradation of CDK6, displaying a DC50 value of 2.1 nM[1].

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