Name: Folate-PEG3-azide
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT212667756
Cas No:1313026-32-2
常用名:Folate-PEG3-azide
IUPAC:(2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-[(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)carbamoyl]butanoic acid
IUPAC:(2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-[(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)carbamoyl]butanoic acid
InChI key:SWFSDYKTNPMWOV-FQEVSTJZSA-N

分子式:C27H35N11O8
分子量:641.646
氢键供体数 (HBD):6
氢键受体数 (HBA):16
LogP:-3.1332672
SMILES:Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)NCCOCCOCCOCCN=[N+]=[N-])C(O)=O)cnc2[nH]1
SMILES:Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)NCCOCCOCCOCCN=[N+]=[N-])C(O)=O)cnc2[nH]1

Folate-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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