Name: mDPR(Boc)-Val-Cit-PAB
Rating: 5 (10 reviews)

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HIT ID:HIT212668004
Cas No:2281797-55-3
常用名:mDPR(Boc)-Val-Cit-PAB
IUPAC:tert-butyl N-[(2S)-2-{[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]carbamate
IUPAC:tert-butyl N-[(2S)-2-{[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]carbamate
InChI key:MFRDXMXKXVDYPI-HFMPRLQTSA-N

分子式:C30H43N7O9
分子量:645.714
氢键供体数 (HBD):7
氢键受体数 (HBA):8
LogP:-0.6369326
SMILES:CC(C)[C@H](NC(=O)[C@H](CNC(=O)OC(C)(C)C)N1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1 |c:20|
SMILES:CC(C)[C@H](NC(=O)[C@H](CNC(=O)OC(C)(C)C)N1C(=O)C=CC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(CO)cc1 |c:20|

mDPR(Boc)-Val-Cit-PAB is a cleavable linker employed in antibody-drug conjugates (ADCs) [1]. This chemical compound serves as a reliable linker in the formation of ADCs, which are biopharmaceuticals that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs for targeted cancer therapy [1].

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