Name: PC Mal-NHS carbonate ester
Rating: 5 (10 reviews)

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HIT ID:HIT212668176
Cas No:1408057-91-9
常用名:PC Mal-NHS carbonate ester
IUPAC:1-[4-(3-{[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]carbamoyl}propoxy)-5-methoxy-2-nitrophenyl]ethyl 2,5-dioxopyrrolidin-1-yl carbonate
IUPAC:1-[4-(3-{[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]carbamoyl}propoxy)-5-methoxy-2-nitrophenyl]ethyl 2,5-dioxopyrrolidin-1-yl carbonate
InChI key:YDJBJIRRIMMTEU-UHFFFAOYSA-N

分子式:C24H26N4O12
分子量:562.488
氢键供体数 (HBD):1
氢键受体数 (HBA):11
LogP:0.3678595
SMILES:COc1cc(C(C)OC(=O)ON2C(=O)CCC2=O)c(cc1OCCCC(=O)NCCN1C(=O)C=CC1=O)[N+]([O-])=O |c:35|
SMILES:COc1cc(C(C)OC(=O)ON2C(=O)CCC2=O)c(cc1OCCCC(=O)NCCN1C(=O)C=CC1=O)[N+]([O-])=O |c:35|

PC Mal-NHS carbonate ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. This chemical compound plays a crucial role in facilitating the conjugation of drugs to antibodies, enabling targeted delivery and enhanced efficacy of therapeutic agents. Its unique carbonate ester structure allows for efficient cleavage in the targeted environment, ensuring the controlled release of the drug payload. Its application in ADC synthesis highlights its importance in the development of innovative and targeted cancer therapies.

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