Name: Phthalimide-PEG4-MPDM-OH
Rating: 5 (10 reviews)

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HIT ID:HIT212668194
Cas No:
常用名:Phthalimide-PEG4-MPDM-OH
IUPAC:2-(2-{2-[2-(2-{[(3R,5S)-5-(hydroxymethyl)-1-methylpyrrolidin-3-yl]oxy}ethoxy)ethoxy]ethoxy}ethyl)-2,3-dihydro-1H-isoindole-1,3-dione
IUPAC:2-(2-{2-[2-(2-{[(3R,5S)-5-(hydroxymethyl)-1-methylpyrrolidin-3-yl]oxy}ethoxy)ethoxy]ethoxy}ethyl)-2,3-dihydro-1H-isoindole-1,3-dione
InChI key:VYZQARMSNCUHEH-ZWKOTPCHSA-N

分子式:C22H32N2O7
分子量:436.505
氢键供体数 (HBD):1
氢键受体数 (HBA):8
LogP:0.06570852
SMILES:CN1C[C@@H](C[C@H]1CO)OCCOCCOCCOCCN1C(=O)c2ccccc2C1=O
SMILES:CN1C[C@@H](C[C@H]1CO)OCCOCCOCCOCCN1C(=O)c2ccccc2C1=O

Phthalimide-PEG4-MPDM-OH, a PROTAC linker with a PEGs composition, has applications in the synthesis of various PROTACs. These PROTACs consist of a linker connecting two distinct ligands: one binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively induce the degradation of target proteins [1].

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