Name: Phthalimide-PEG4-PDM-OTBS
Rating: 5 (10 reviews)

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HIT ID:HIT212668195
Cas No:
常用名:Phthalimide-PEG4-PDM-OTBS
IUPAC:2-(2-{2-[2-(2-{[(3R,5S)-5-{[(tert-butyldimethylsilyl)oxy]methyl}pyrrolidin-3-yl]oxy}ethoxy)ethoxy]ethoxy}ethyl)-2,3-dihydro-1H-isoindole-1,3-dione
IUPAC:2-(2-{2-[2-(2-{[(3R,5S)-5-{[(tert-butyldimethylsilyl)oxy]methyl}pyrrolidin-3-yl]oxy}ethoxy)ethoxy]ethoxy}ethyl)-2,3-dihydro-1H-isoindole-1,3-dione
InChI key:NLFPGFSSIZQXNJ-FCHUYYIVSA-N

分子式:C27H44N2O7Si
分子量:536.741
氢键供体数 (HBD):1
氢键受体数 (HBA):8
LogP:1.7205
SMILES:CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@H](CN1)OCCOCCOCCOCCN1C(=O)c2ccccc2C1=O
SMILES:CC(C)(C)[Si](C)(C)OC[C@@H]1C[C@H](CN1)OCCOCCOCCOCCN1C(=O)c2ccccc2C1=O

Phthalimide-PEG4-PDM-OTBS is a PROTAC linker comprised of polyethylene glycols (PEGs). This compound is utilized in the synthesis of a range of PROTACs, which consists of two distinct ligands connected by a linker. One ligand binds to an E3 ubiquitin ligase, while the other ligand binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins[1].

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