Name: Pyrene-PEG2-azide
Rating: 5 (10 reviews)

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HIT ID:HIT212668283
Cas No:2135330-58-2
常用名:Pyrene-PEG2-azide
IUPAC:N-{2-[2-(2-azidoethoxy)ethoxy]ethyl}pyrene-1-carboxamide
IUPAC:N-{2-[2-(2-azidoethoxy)ethoxy]ethyl}pyrene-1-carboxamide
InChI key:CXNRBKHYGKLDHH-UHFFFAOYSA-N

分子式:C23H22N4O3
分子量:402.454
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:3.3945353
SMILES:[N-]=[N+]=NCCOCCOCCNC(=O)c1ccc2ccc3cccc4ccc1c2c34
SMILES:[N-]=[N+]=NCCOCCOCCNC(=O)c1ccc2ccc3cccc4ccc1c2c34

Pyrene-PEG2-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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