Name: (S,R,S)-AHPC-C3-NH2 TFA (2361119-88-0 free base)
Rating: 5 (10 reviews)

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HIT ID:HIT212668298
Cas No:2688842-02-4
常用名:(S,R,S)-AHPC-C3-NH2 TFA (2361119-88-0 free base)
常用名:(S,R,S)-AHPC-C3-NH2 TFA (2361119-88-0 free base)
别名:VH032-C3-NH2 TFA, (S,R,S)-AHPC-C3-NH2 TFA
别名:VH032-C3-NH2 TFA, (S,R,S)-AHPC-C3-NH2 TFA
IUPAC:(2S,4R)-1-[(2S)-2-(4-aminobutanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide; trifluoroacetic acid
IUPAC:(2S,4R)-1-[(2S)-2-(4-aminobutanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide; trifluoroacetic acid
InChI key:MDVHDVIBUKXMTL-XUXADIIKSA-N

分子式:C28H38F3N5O6S
分子量:629.7
氢键供体数 (HBD):4
氢键受体数 (HBA):6
LogP:0.2709254
SMILES:OC(=O)C(F)(F)F.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN)C(C)(C)C)cc1
SMILES:OC(=O)C(F)(F)F.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN)C(C)(C)C)cc1

(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852. UNC6852 is an EED-targeted bivalent chemical degrader[1].

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