(S,R,S)-AHPC-C5-COOH | VH032-C5-COOH | CAS 2267282-19-7 | AnyMole

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HIT212668302

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HIT212668302

HIT ID:HIT212668302
Cas No:2267282-19-7
常用名:(S,R,S)-AHPC-C5-COOH
别名:VH032-C5-COOH
IUPAC:7-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino}heptanoic acid
IUPAC:7-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino}heptanoic acid
InChI key:SCVBFBWIXTXYQE-MVERNJQCSA-N

分子式:C29H42N4O5S
分子量:558.74
氢键供体数 (HBD):4
氢键受体数 (HBA):7
LogP:0.14753233
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NCCCCCCC(O)=O)C(C)(C)C)cc1
SMILES:Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NCCCCCCC(O)=O)C(C)(C)C)cc1

(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].

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