Name: Thalidomide-NH-PEG7
Rating: 5 (10 reviews)

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HIT ID:HIT212668441
Cas No:
常用名:Thalidomide-NH-PEG7
IUPAC:2-(2,6-dioxopiperidin-3-yl)-4-(21-hydroxy-4,7,10,13,16,19-hexaoxa-1-azahenicosan-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione
IUPAC:2-(2,6-dioxopiperidin-3-yl)-4-(21-hydroxy-4,7,10,13,16,19-hexaoxa-1-azahenicosan-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione
InChI key:FDUDLKYDKJZCFR-UHFFFAOYSA-N

分子式:C27H39N3O11
分子量:581.619
氢键供体数 (HBD):3
氢键受体数 (HBA):12
LogP:-0.83346957
SMILES:OCCOCCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
SMILES:OCCOCCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

Thalidomide-NH-PEG7 is a synthesized conjugate of an E3 ligase ligand and linker designed for use in antibody-drug conjugates (ADCs). This compound can be coupled to a protein ligand via a linker to create PROTAC iRucaparib-AP6, an extremely selective degrader of PARP1[1].

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