VHL Ligand-Linker Conjugates 17 | AnyMole

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HIT212668478

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HIT212668478

HIT ID:HIT212668478
Cas No:
常用名:VHL Ligand-Linker Conjugates 17
IUPAC:4-(2-{1-[(3S)-3-{[(2S,4R)-4-hydroxy-1-[(2R)-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoyl]piperidin-4-yl}ethynyl)benzoic acid
IUPAC:4-(2-{1-[(3S)-3-{[(2S,4R)-4-hydroxy-1-[(2R)-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoyl]piperidin-4-yl}ethynyl)benzoic acid
InChI key:FRIZMJMVXZSQGB-MNHGUUTPSA-N

分子式:C37H42N4O7
分子量:654.764
氢键供体数 (HBD):3
氢键受体数 (HBA):7
LogP:2.8489292
SMILES:CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CC(=O)N1CCC(CC1)C#Cc1ccc(cc1)C(O)=O)c1ccccc1)c1cc(C)no1
SMILES:CC(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CC(=O)N1CCC(CC1)C#Cc1ccc(cc1)C(O)=O)c1ccccc1)c1cc(C)no1

VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, including the notable ARD-266. ARD-266 is an exceptionally effective androgen receptor (AR) PROTAC degrader[1].

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