Name: DBCO-NHCO-PEG4-amine
Rating: 5 (10 reviews)

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HIT ID:HIT212668820
Cas No:1255942-08-5
常用名:DBCO-NHCO-PEG4-amine
IUPAC:1-amino-N-(3-{2-azatricyclo[10.4.0.0^{4,9}]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-3-oxopropyl)-3,6,9,12-tetraoxapentadecan-15-amide
IUPAC:1-amino-N-(3-{2-azatricyclo[10.4.0.0^{4,9}]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-3-oxopropyl)-3,6,9,12-tetraoxapentadecan-15-amide
InChI key:KTIOBJVNCOFWCL-UHFFFAOYSA-N

分子式:C29H37N3O6
分子量:523.63
氢键供体数 (HBD):2
氢键受体数 (HBA):7
LogP:1.2040293
SMILES:NCCOCCOCCOCCOCCC(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12
SMILES:NCCOCCOCCOCCOCCC(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].

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