Name: Hydroxy-PEG3-PFP ester
Rating: 5 (10 reviews)

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HIT ID:HIT212668907
Cas No:1807537-40-1
常用名:Hydroxy-PEG3-PFP ester
IUPAC:2,3,4,5,6-pentafluorophenyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate
IUPAC:2,3,4,5,6-pentafluorophenyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate
InChI key:MDIKFXKPNIRFLO-UHFFFAOYSA-N

分子式:C15H17F5O6
分子量:388.287
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:1.5728546
SMILES:OCCOCCOCCOCCC(=O)Oc1c(F)c(F)c(F)c(F)c1F
SMILES:OCCOCCOCCOCCC(=O)Oc1c(F)c(F)c(F)c(F)c1F

Hydroxy-PEG3-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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