Name: Maleimido-tri(ethylene glycol)-propionic acid
Rating: 5 (10 reviews)

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HIT ID:HIT212669017
Cas No:518044-40-1
常用名:Maleimido-tri(ethylene glycol)-propionic acid
常用名:Maleimido-tri(ethylene glycol)-propionic acid
别名:Mal-PEG3-acid
IUPAC:3-(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)propanoic acid
IUPAC:3-(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)propanoic acid
InChI key:YSFOTVPQFVYTQX-UHFFFAOYSA-N

分子式:C13H19NO7
分子量:301.295
氢键供体数 (HBD):1
氢键受体数 (HBA):7
LogP:-0.83815736
SMILES:OC(=O)CCOCCOCCOCCN1C(=O)C=CC1=O
SMILES:OC(=O)CCOCCOCCOCCN1C(=O)C=CC1=O

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1].

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