Name: Tos-PEG4-CH2COOH
Rating: 5 (10 reviews)

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HIT ID:HIT212669267
Cas No:2028284-73-1
常用名:Tos-PEG4-CH2COOH
IUPAC:14-[(4-methylbenzenesulfonyl)oxy]-3,6,9,12-tetraoxatetradecanoic acid
IUPAC:14-[(4-methylbenzenesulfonyl)oxy]-3,6,9,12-tetraoxatetradecanoic acid
InChI key:MTBIBZOLTXFDIU-UHFFFAOYSA-N

分子式:C17H26O9S
分子量:406.45
氢键供体数 (HBD):1
氢键受体数 (HBA):8
LogP:1.3356159
SMILES:Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCC(O)=O
SMILES:Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCC(O)=O

Tos-PEG4-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

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