Name: Akt1 and Akt2-IN-1
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT212669296
Cas No:893422-47-4
常用名:Akt1 and Akt2-IN-1
IUPAC:3-phenyl-2-[4-({4-[5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl]piperidin-1-yl}methyl)phenyl]-5,6-dihydro-1,6-naphthyridin-5-one
IUPAC:3-phenyl-2-[4-({4-[5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl]piperidin-1-yl}methyl)phenyl]-5,6-dihydro-1,6-naphthyridin-5-one
InChI key:BTUWHHFNOHVCMQ-UHFFFAOYSA-N

分子式:C33H29N7O
分子量:539.643
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:4.5719223
SMILES:O=c1[nH]ccc2nc(-c3ccc(CN4CCC(CC4)c4n[nH]c(n4)-c4ccccn4)cc3)c(cc12)-c1ccccc1
SMILES:O=c1[nH]ccc2nc(-c3ccc(CN4CCC(CC4)c4n[nH]c(n4)-c4ccccn4)cc3)c(cc12)-c1ccccc1

Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM). It has potent and balanced activity.

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