Name: AMD 3465
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT212669321
Cas No:185991-24-6
常用名:AMD 3465
别名:GENZ-644494
IUPAC:[(pyridin-2-yl)methyl]({4-[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]phenyl}methyl)amine
IUPAC:[(pyridin-2-yl)methyl]({4-[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]phenyl}methyl)amine
InChI key:CWJJHESJXJQCJA-UHFFFAOYSA-N

分子式:C24H38N6
分子量:410.61
氢键供体数 (HBD):4
氢键受体数 (HBA):6
LogP:0.9164483
SMILES:C(NCc1ccccn1)c1ccc(CN2CCCNCCNCCCNCC2)cc1
SMILES:C(NCc1ccccn1)c1ccc(CN2CCCNCCNCCCNCC2)cc1

AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.

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