Name: AVX 13616
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212669391
Cas No:900814-48-4
常用名:AVX 13616
IUPAC:3-methylbutyl 2-{2-[6-amino-2-(2-{[2'-(3-methylbutoxy)-[1,1'-binaphthalen]-2-yl]oxy}acetamido)hexanamido]-5-carbamimidamidopentanamido}-4-methylpentanoate dihydrochloride
IUPAC:3-methylbutyl 2-{2-[6-amino-2-(2-{[2'-(3-methylbutoxy)-[1,1'-binaphthalen]-2-yl]oxy}acetamido)hexanamido]-5-carbamimidamidopentanamido}-4-methylpentanoate dihydrochloride
InChI key:SINJZCNZEBJUKD-UHFFFAOYSA-N

分子式:C50H73Cl2N7O7
分子量:955.08
氢键供体数 (HBD):7
氢键受体数 (HBA):10
LogP:6.274088
SMILES:Cl.Cl.CC(C)CCOC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCCN)NC(=O)COc1ccc2ccccc2c1-c1c(OCCC(C)C)ccc2ccccc12
SMILES:Cl.Cl.CC(C)CCOC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCCN)NC(=O)COc1ccc2ccccc2c1-c1c(OCCC(C)C)ccc2ccccc12

AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens. IC50 value: 2-4 ug/ml (MICs) Target: antibacterial agent AVX13616 was as active as mupirocin in a nasal decolonization model but required only a single application. AVX13616 and other compounds showed broad spectrum antibacterial activity against a range of isolates with MICs of 2-4 micrograms per millilitre against S. aureus, coagulase negative staphylococci, enterococci, MRSA, VISA and VRSA. The compounds are being developed for topical indications and/or wound infection/catheter-related infections. A single application of 5% (w/w) AVX13616 (approximately equimolar to 2% mupirocin) was as effective as 2% mupirocin administered twice a day for five days in nasal decolonisation of MRSA in mice.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~