Name: BAZ2-ICR
Rating: 5 (10 reviews)

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HIT ID:HIT212669443
Cas No:1665195-94-7
常用名:BAZ2-ICR
IUPAC:4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile
IUPAC:4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile
InChI key:RRZVGDGTWNQAPW-UHFFFAOYSA-N

分子式:C20H19N7
分子量:357.421
氢键供体数 (HBD):0
氢键受体数 (HBA):4
LogP:2.4037046
SMILES:Cn1cc(CCn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
SMILES:Cn1cc(CCn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1

BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains.

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