Name: BMT-090605
Rating: 5 (10 reviews)

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HIT ID:HIT212669506
Cas No:1551403-51-0
常用名:BMT-090605
IUPAC:8-{[(2S)-2-amino-4-methylpentyl]oxy}-4,6-dimethyl-5-oxo-5H,6H-benzo[c]2,7-naphthyridine-9-carbonitrile
IUPAC:8-{[(2S)-2-amino-4-methylpentyl]oxy}-4,6-dimethyl-5-oxo-5H,6H-benzo[c]2,7-naphthyridine-9-carbonitrile
InChI key:NQXBZPJVVGIFBJ-HNNXBMFYSA-N

分子式:C21H24N4O2
分子量:364.449
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:2.0890002
SMILES:CC(C)C[C@H](N)COc1cc2n(C)c(=O)c3c(C)nccc3c2cc1C#N
SMILES:CC(C)C[C@H](N)COc1cc2n(C)c(=O)c3c(C)nccc3c2cc1C#N

BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 shows antinociceptive activity.

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