Name: Ravoxertinib hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212670217
Cas No:2070009-58-2
常用名:Ravoxertinib hydrochloride
别名:GDC-0994 (hydrochloride)
IUPAC:1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-{2-[(1-methyl-1H-pyrazol-5-yl)amino]pyrimidin-4-yl}-1,2-dihydropyridin-2-one hydrochloride
IUPAC:1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-{2-[(1-methyl-1H-pyrazol-5-yl)amino]pyrimidin-4-yl}-1,2-dihydropyridin-2-one hydrochloride
InChI key:RMNVBUVHPAETTJ-GMUIIQOCSA-N

分子式:C21H19Cl2FN6O2
分子量:477.32
氢键供体数 (HBD):2
氢键受体数 (HBA):6
LogP:2.6955242
SMILES:Cl.Cn1nccc1Nc1nccc(n1)-c1ccn([C@H](CO)c2ccc(Cl)c(F)c2)c(=O)c1
SMILES:Cl.Cn1nccc1Nc1nccc(n1)-c1ccn([C@H](CO)c2ccc(Cl)c(F)c2)c(=O)c1

Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).

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