Name: GNE-618
Rating: 5 (10 reviews)

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HIT ID:HIT212670236
Cas No:1362151-42-5
常用名:GNE-618
IUPAC:N-({4-[3-(trifluoromethyl)benzenesulfonyl]phenyl}methyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
IUPAC:N-({4-[3-(trifluoromethyl)benzenesulfonyl]phenyl}methyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
InChI key:LKBHAGGICJWHQQ-UHFFFAOYSA-N

分子式:C21H15F3N4O3S
分子量:460.43
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:3.07757
SMILES:FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1
SMILES:FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1

GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM). GNE-618 depletes NAD levels and induces tumor cell death. It has anti-tumor activity.

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