Name: RTC-5
Rating: 5 (10 reviews)

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HIT ID:HIT212670271
Cas No:1423077-49-9
常用名:RTC-5
别名:TRC-382
IUPAC:N-(3-{5-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)-4-(trifluoromethoxy)benzene-1-sulfonamide
IUPAC:N-(3-{5-chloro-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)-4-(trifluoromethoxy)benzene-1-sulfonamide
InChI key:QYOJMNDDVVEPFN-UHFFFAOYSA-N

分子式:C24H22ClF3N2O3S
分子量:510.96
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:8.117
SMILES:FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NCCCN1c2ccccc2CCc2ccc(Cl)cc12
SMILES:FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NCCCN1c2ccccc2CCc2ccc(Cl)cc12

RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness against an EGFR-driven cancer xenograft model. The mechanism behind its efficacy can be attributed to the simultaneous inhibition of PI3K-AKT and RAS-ERK signaling pathways.

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