Name: SB-277011 dihydrochloride
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT212670346
Cas No:1226917-67-4
常用名:SB-277011 dihydrochloride
别名:SB-277011A dihydrochloride
IUPAC:N-[(1r,4r)-4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide dihydrochloride
IUPAC:N-[(1r,4r)-4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide dihydrochloride
InChI key:HEZIOTGUXSPDAK-ONAIBGCWSA-N

分子式:C28H32Cl2N4O
分子量:511.49
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:4.628601
SMILES:Cl.Cl.O=C(N[C@H]1CC[C@H](CCN2CCc3cc(ccc3C2)C#N)CC1)c1ccnc2ccccc12 |wU:5.2,wD:8.6,(15.92,,;-.77,-8.96,;-2.71,-3.57,;-4.04,-2.8,;-4.04,-1.26,;-2.71,-.49,;-2.71,1.05,;-1.37,1.82,;-.04,1.05,;1.29,1.82,;2.63,1.05,;3.96,1.82,;3.96,3.36,;5.29,4.13,;6.63,3.36,;7.96,4.13,;9.3,3.36,;9.3,1.82,;7.96,1.05,;6.63,1.82,;5.29,1.05,;10.63,4.13,;11.96,4.9,;-.04,-.49,;-1.37,-1.26,;-5.38,-3.57,;-5.38,-5.11,;-6.71,-5.88,;-8.04,-5.11,;-8.04,-3.57,;-9.38,-2.8,;-9.38,-1.26,;-8.04,-.49,;-6.71,-1.26,;-6.71,-2.8,)|
SMILES:Cl.Cl.O=C(N[C@H]1CC[C@H](CCN2CCc3cc(ccc3C2)C#N)CC1)c1ccnc2ccccc12 |wU:5.2,wD:8.6,(15.92,,;-.77,-8.96,;-2.71,-3.57,;-4.04,-2.8,;-4.04,-1.26,;-2.71,-.49,;-2.71,1.05,;-1.37,1.82,;-.04,1.05,;1.29,1.82,;2.63,1.05,;3.96,1.82,;3.96,3.36,;5.29,4.13,;6.63,3.36,;7.96,4.13,;9.3,3.36,;9.3,1.82,;7.96,1.05,;6.63,1.82,;5.29,1.05,;10.63,4.13,;11.96,4.9,;-.04,-.49,;-1.37,-1.26,;-5.38,-3.57,;-5.38,-5.11,;-6.71,-5.88,;-8.04,-5.11,;-8.04,-3.57,;-9.38,-2.8,;-9.38,-1.26,;-8.04,-.49,;-6.71,-1.26,;-6.71,-2.8,)|

SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~