Sitravatinib malate | MGCD516 malate | MG-516 malate | CAS 2244864-88-6 | AnyMole

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HIT212670419

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HIT212670419

HIT ID:HIT212670419
Cas No:2244864-88-6
常用名:Sitravatinib malate
别名:MGCD516 malate, MG-516 malate
IUPAC:(2S)-2-hydroxybutanedioic acid; N'1-(3-fluoro-4-{[2-(5-{[(2-methoxyethyl)amino]methyl}pyridin-2-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
IUPAC:(2S)-2-hydroxybutanedioic acid; N'1-(3-fluoro-4-{[2-(5-{[(2-methoxyethyl)amino]methyl}pyridin-2-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
InChI key:GDLGZWLGDROYHH-WNQIDUERSA-N

分子式:C37H35F2N5O9S
分子量:763.77
氢键供体数 (HBD):3
氢键受体数 (HBA):6
LogP:5.3261375
SMILES:O[C@@H](CC(O)=O)C(O)=O.COCCNCc1ccc(nc1)-c1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c2s1
SMILES:O[C@@H](CC(O)=O)C(O)=O.COCCNCc1ccc(nc1)-c1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c2s1

Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively.) , shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

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供应商
TargetMolSC
规格
货期
1-2周
纯度
-
¥ 10,600.00
1

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