Name: (S,R,S)-AHPC-Me dihydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT212670678
Cas No:2504950-56-3
常用名:(S,R,S)-AHPC-Me dihydrochloride
别名:VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
别名:VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
IUPAC:(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide dihydrochloride
IUPAC:(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide dihydrochloride
InChI key:YTJDUDNKHHNDRD-ARZBPYMHSA-N

分子式:C23H34Cl2N4O3S
分子量:517.51
氢键供体数 (HBD):3
氢键受体数 (HBA):5
LogP:2.383
SMILES:Cl.Cl.C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
SMILES:Cl.Cl.C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C

(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demonstrates potent degradation of BET protein in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound serves as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, that facilitates the recruitment of von Hippel-Lindau (VHL) protein.

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