Name: EG01377
Rating: 5 (10 reviews)

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HIT ID:HIT212670691
Cas No:2227996-00-9
常用名:EG01377
IUPAC:(2S)-2-[(3-{5-[4-(aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-sulfonamido}thiophen-2-yl)formamido]-5-[(diaminomethylidene)amino]pentanoic acid
IUPAC:(2S)-2-[(3-{5-[4-(aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-sulfonamido}thiophen-2-yl)formamido]-5-[(diaminomethylidene)amino]pentanoic acid
InChI key:SEXUXSMBJLNXIR-FQEVSTJZSA-N

分子式:C26H30N6O6S2
分子量:586.68
氢键供体数 (HBD):6
氢键受体数 (HBA):10
LogP:-3.763127
SMILES:[#7]-[#6]-c1ccc(cc1)-c1cc2-[#6]-[#6]-[#8]-c2c(c1)S(=O)(=O)[#7]-c1ccsc1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O
SMILES:[#7]-[#6]-c1ccc(cc1)-c1cc2-[#6]-[#6]-[#8]-c2c(c1)S(=O)(=O)[#7]-c1ccsc1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O

EG01377 has antiangiogenic, antimigratory, and antitumor effects.EG01377 is a neuropilin-1 (NRP1) antagonist, with a Kd of 1.32 μM for NRP1-b1, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1, but shows no effect on NRP2.

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