Name: ELN318463
Rating: 5 (10 reviews)

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HIT ID:HIT212670718
Cas No:851600-86-7
常用名:ELN318463
别名:ELN 318463
IUPAC:N-[(4-bromophenyl)methyl]-4-chloro-N-[(3R)-2-oxoazepan-3-yl]benzene-1-sulfonamide
IUPAC:N-[(4-bromophenyl)methyl]-4-chloro-N-[(3R)-2-oxoazepan-3-yl]benzene-1-sulfonamide
InChI key:KTCJYACFOQWRDO-GOSISDBHSA-N

分子式:C19H20BrClN2O3S
分子量:471.79
氢键供体数 (HBD):1
氢键受体数 (HBA):3
LogP:4.0809383
SMILES:Clc1ccc(cc1)S(=O)(=O)N(Cc1ccc(Br)cc1)[C@@H]1CCCCNC1=O
SMILES:Clc1ccc(cc1)S(=O)(=O)N(Cc1ccc(Br)cc1)[C@@H]1CCCCNC1=O

ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.

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