Name: EMT inhibitor-2
Rating: 5 (10 reviews)

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HIT ID:HIT212670729
Cas No:2232228-60-1
常用名:EMT inhibitor-2
IUPAC:4-(2-{[2-(3,4-dimethoxyphenyl)-5-hydroxy-6-methoxy-4-oxo-4H-chromen-7-yl]oxy}ethyl)piperazin-2-one
IUPAC:4-(2-{[2-(3,4-dimethoxyphenyl)-5-hydroxy-6-methoxy-4-oxo-4H-chromen-7-yl]oxy}ethyl)piperazin-2-one
InChI key:QOLZDEMWVAPPHO-UHFFFAOYSA-N

分子式:C24H26N2O8
分子量:470.478
氢键供体数 (HBD):2
氢键受体数 (HBA):9
LogP:1.4249711
SMILES:COc1ccc(cc1OC)-c1cc(=O)c2c(O)c(OC)c(OCCN3CCNC(=O)C3)cc2o1
SMILES:COc1ccc(cc1OC)-c1cc(=O)c2c(O)c(OC)c(OCCN3CCNC(=O)C3)cc2o1

EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC50s of 49.72 and 5.54 μM, respectively. EMT inhibitor-2 inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes.

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