Name: Ethacrynic acid D5
Rating: 5 (10 reviews)

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HIT ID:HIT212670782
Cas No:1330052-59-9
常用名:Ethacrynic acid D5
IUPAC:2-{2,3-dichloro-4-[2-methylidene(3,3,4,4,4-2H5)butanoyl]phenoxy}acetic acid
IUPAC:2-{2,3-dichloro-4-[2-methylidene(3,3,4,4,4-2H5)butanoyl]phenoxy}acetic acid
InChI key:AVOLMBLBETYQHX-WNWXXORZSA-N

分子式:C13H12Cl2O4
分子量:308.17
氢键供体数 (HBD):1
氢键受体数 (HBA):4
LogP:3.655707
SMILES:[2H]C([2H])([2H])C([2H])([2H])C(=C)C(=O)c1ccc(OCC(O)=O)c(Cl)c1Cl
SMILES:[2H]C([2H])([2H])C([2H])([2H])C(=C)C(=O)c1ccc(OCC(O)=O)c(Cl)c1Cl

Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by its deuterium labeling.

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