Name: FGTI-2734 mesylate (1247018-19-4 free base)
Rating: 5 (10 reviews)

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HIT ID:HIT212670822
Cas No:2702297-24-1
常用名:FGTI-2734 mesylate (1247018-19-4 free base)
常用名:FGTI-2734 mesylate (1247018-19-4 free base)
别名:FGTI-2734 mesylate
IUPAC:N-{2-[(4-cyano-2-fluorophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl}-N-(cyclohexylmethyl)pyridine-2-sulfonamide; methanesulfonic acid
IUPAC:N-{2-[(4-cyano-2-fluorophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl}-N-(cyclohexylmethyl)pyridine-2-sulfonamide; methanesulfonic acid
InChI key:CVSSKDKRVCBPOV-UHFFFAOYSA-N

分子式:C27H35FN6O5S2
分子量:606.73
氢键供体数 (HBD):0
氢键受体数 (HBA):6
LogP:4.17594
SMILES:CS(O)(=O)=O.Cn1cncc1CN(CCN(CC1CCCCC1)S(=O)(=O)c1ccccn1)c1ccc(cc1F)C#N
SMILES:CS(O)(=O)=O.Cn1cncc1CN(CCN(CC1CCCCC1)S(=O)(=O)c1ccccn1)c1ccc(cc1F)C#N

FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.

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