Name: Finafloxacin
Rating: 5 (10 reviews)

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HIT ID:HIT212670827
Cas No:209342-40-5
常用名:Finafloxacin
别名:非那沙星
IUPAC:7-[(4aS,7aS)-octahydropyrrolo[3,4-b][1,4]oxazin-6-yl]-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
IUPAC:7-[(4aS,7aS)-octahydropyrrolo[3,4-b][1,4]oxazin-6-yl]-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChI key:FYMHQCNFKNMJAV-HOTGVXAUSA-N

分子式:C20H19FN4O4
分子量:398.394
氢键供体数 (HBD):2
氢键受体数 (HBA):8
LogP:-1.0753613
SMILES:[H][C@]12CN(C[C@]1([H])OCCN2)c1c(F)cc2c(c1C#N)n(cc(C(O)=O)c2=O)C1CC1
SMILES:[H][C@]12CN(C[C@]1([H])OCCN2)c1c(F)cc2c(c1C#N)n(cc(C(O)=O)c2=O)C1CC1

Finafloxacin, a fluoroquinolone antimicrobial agent from a new 8-cyano subclass, is most effective in slightly acidic environments (pH 5.0-6.0), a condition where other fluoroquinolones typically reduce in activity. It selectively targets bacterial type II topoisomerases, such as DNA gyrase and DNA topoisomerase IV, making it suitable for treating serious bacterial infections particularly in acidic contexts, including urinary tract infections (UTIs) and Helicobacter pylori infections.

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